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KMID : 0604220070140020051
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Korean Journal Investigative Dermatology
2007 Volume.14 No. 2 p.51 ~ p.56
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Effect of X-ray on the Expression of p53 in Human Skin Tissue Cultured in Vitro
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Choi Dae-Kyoung
Lee Jeung-Hoon
Kim Chang-Duk
Lee Kyung-Moon
Kim Ki-Hwan
Cho Moon-June
Lee Young-Sook
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Abstract
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X-ray irradiation is widely used treatment in most cancers and it affects the cancer cell damage. Skin reactions are the most common side effects observed in response to x-ray treatment. p53, a tumor suppressor gene has been known to play very important roles in the reactions to the damage caused by x-ray irradiation. In several cell cultures or animal models, X-ray irradiation-induced DNA damage in human keratinocytes has been shown to induce p53 expression and apoptosis. In this study, we investigated epidermal p53 response caused by x-ray irradiaton in a skin organ culture model. In result, the epidermal irradiation responses and repair kinetics in a skin organ culture were similar to what was found in vivo. Our data suggest that organ-cultured skin provides a valuable tool for studies of x-ray radiation-induced epidermal responses.
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KEYWORD
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X-rays, p53, Skin organ culture, Radio-dermatitis
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